| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594903 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A series of novel 1,4-diamine-based CYP3A inhibitors were designed and evaluated. A potent and selective inhibitor of CYP3A, cobicistat (35, GS-9350) was discovered as a novel pharmacoenhancer.
Related Topics
Physical Sciences and Engineering
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Authors
Lianhong Xu, Hongtao Liu, Allen Hong, Randy Vivian, Bernard P. Murray, Christian Callebaut, You-Chul Choi, Melody S. Lee, Jennifer Chau, Luong K. Tsai, Kirsten M. Stray, Robert G. Strickley, Jianhong Wang, Leah Tong, Swami Swaminathan, Gerry R. Rhodes,