| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594916 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A novel family of 1H-imidazol-2-yl-pyrimidine-4,6-diamines has been identified with potent activity against the erythrocyte-stage of Plasmodium falciparum (Pf), the most common causative agent of malaria. A systematic SAR study resulted in the identification of compound 40 which exhibits good potency against both wild-type and drug resistant parasites and exhibits good in vivo pharmacokinetic properties.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xianming Deng, Advait Nagle, Tao Wu, Tomoyo Sakata, Kerstin Henson, Zhong Chen, Kelli Kuhen, David Plouffe, Elizabeth Winzeler, Francisco Adrian, Tove Tuntland, Jonathan Chang, Susan Simerson, Steven Howard, Jared Ek, John Isbell, David C. Tully,