Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594968 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A diastereomeric and regioisomeric library of 10-substituted triazolyl artemisinin compounds (6a-6h, 7a-7h, and 8a-8h) with a potent growth inhibitory activities against various cancer cell lines was established. These compounds were synthesized by a reaction with dihydroartemisinin (2) and various substituted triazoles (5a-5h) in methylene chloride using a BF3Et2O catalyst. Most of the compounds exhibited a strong potency in the submicromolar range, and, in particular, 6f, 7f, and 8f, which have a pentylphenyltriazole moiety, proved to be promising candidates for preclinical trials.
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Authors
Sangtae Oh, Woon-Seob Shin, Jungyeob Ham, Seokjoon Lee,