| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594978 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
In our program to search new AMPK activators from plants, seven 2,5-bis-aryl-3,4-dimethyltetrahydrofuran lignans, tetrahydrofuroguaiacin B (1), saucernetindiol (2), verrucosin (3), nectandrin B (4), nectandrin A (5), fragransin C1 (6), and galbacin (7) were isolated from Myristica fragrans (nutmeg). Among the isolates, compounds 1, 4, and 5 at 5 μM produced strong AMPK stimulation in differentiated C2C12 cells. The active fraction containing of high content of nectandrin B showed protective effect on the increase of blood glucose and body weight in high-fat diet (HFD)-induced mice.
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Authors
Phi Hung Nguyen, Thi Van Thu Le, Hu Won Kang, Jooyoung Chae, Sang Kyum Kim, Kwang-iI Kwon, Dae Bang Seo, Sang Jun Lee, Won Keun Oh,