Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10594996 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Folacin C60 derivative has been synthesised and characterized in our recent research. As a novel derivative of C60, the folacin C60 derivative is soluble in H2O which behaves as a free radical scavenger. Rat pheochromocytoma cells treated with hydrogen peroxide underwent cytotoxicity and apoptotic death is determined by MTT assay and flow cytometry analysis. The results suggest that folacin C60 derivative has the potential to prevent oxidative stress-induced cell death without evident toxicity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhen Hu, Wenchao Guan, Wei Wang, Zhou Zhu, Yanhong Wang,