| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10594998 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The bioassay tests showed that compounds 6e and 6f exhibited certain effective against gastric SGC-7901 cell with the IC50 values were 22.28 ± 6.26 and 18.45 ± 2.79 μg/mL, respectively. Compound 6e can strongly inhibit telomerase with IC50 value of 0.8 ± 0.07 μg/mL. The docking simulation result shows that some 2-chloro-pyridine containing flavone (6e) can combine well with the telomerase active site may use as potential telomerase inhibitors.
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Chemistry
Organic Chemistry
Authors
Xin-Hua Liu, Hui-Feng Liu, Xu Shen, Bao-An Song, Pinaki S. Bhadury, Hai-Liang Zhu, Jin-Xing Liu, Xing-Bao Qi,