| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595018 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
In this Letter, we describe the synthesis of constrained diazepanes including 3,9-diazabicyclo[4.2.1]nonane 8a that has improved oral bioavailability and sleep-promoting activity in a rat EEG model.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat](/preview/png/10595018.png "First Page Preview: Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat")
Authors
Paul J. Coleman, John D. Schreier, Anthony J. Roecker, Swati P. Mercer, Georgia B. McGaughey, Christopher D. Cox, George D. Hartman, C. Meacham Harrell, Duane R. Reiss, Scott M. Doran, Susan L. Garson, Wayne B. Anderson, Cuyue Tang,