| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595023 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2.
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Authors
Sangtae Oh, Byong-Gon Park, Jungyeob Ham, Seokjoon Lee,