| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595077 | Bioorganic & Medicinal Chemistry Letters | 2013 | 17 Pages |
Abstract
A series of Nâ²1,Nâ²3-dialkyl-Nâ²1,Nâ²3-di(alkylcarbonothioyl) malonohydrazides have been designed and synthesized as anticancer agents by targeting oxidative stress and Hsp70 induction. Structure-activity relationship (SAR) studies lead to the discovery of STA-4783 (elesclomol), a novel small molecule that has been evaluated in a number of clinical trials as an anticancer agent in combination with Taxol.
Related Topics
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Authors
Shoujun Chen, Lijun Sun, Keizo Koya, Noriaki Tatsuta, Zhiqiang Xia, Timothy Korbut, Zhenjian Du, Jim Wu, Guiqing Liang, Jun Jiang, Mitsunori Ono, Dan Zhou, Andrew Sonderfan,