| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595117 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A novel protocol based on size-exclusion chromatography (SEC) and MS was established to accelerate dynamic combinatorial chemistry (DCC) in this study. By isolating ligand-target adducts from the dynamic combinatorial library (DCL), ligands could be identified directly by MS after denaturation. Three new inhibitors for lysozyme were discovered by this SEC-MS protocol in a case study. Km Data for these new inhibitors was also determined.
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Authors
Zheng Fang, Wei He, Xin Li, Zhengjiang Li, Beining Chen, Pingkai Ouyang, Kai Guo,