Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595125 | Bioorganic & Medicinal Chemistry Letters | 2013 | 14 Pages |
Abstract
Pd(II), Cu(II) and Zn(II) complexes (1-3) based on 4â²-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-2,2â²:6â²,2â³-terpyridine were synthesized and characterized by UV, IR, NMR, EPR, HRMS, elemental analyses, and molar conductivity measurements. The cytotoxicity of these complexes against HL-60, BGC-823, KB, Bel-7402, A549, Hela, K562 and MCF-7 cell lines in vitro was measured by MTT method. The DNA binding property of the complexes was evaluated by UV, fluorescence, CD spectroscopies and thermal denaturation. The cytotoxicity of complexes 1 and 3 against all the tested cell lines is better than that of cisplatin. Complexes 1 and 2 exhibit 7- and 4-folds higher cytotoxicity than cisplatin against Bel-7402 cell line. Complex 3 displays the highest cytotoxicity against all the cell lines tested, and shows 7-, 14-, 8-, 11- and 8-folds higher cytotoxicity than cisplatin against Bel-7402, A549, Hela, K562 and MCF-7 cell lines. The complexes bind to DNA via intercalation mode and complex 3 stabilizes the G-quadruplex. The results reveal that all the complexes display high cytotoxicity against all the tested cancer cell lines, and complex 3 is selective for G-quadruplex over duplex DNA.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wenhao Chu, Yuechai Wang, Siyuan Liu, Xueyun Yang, Shuxiang Wang, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chuanqi Zhou, Jinchao Zhang,