Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595169 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The structural analogs of epibatidine and epiboxidine (±)-10-(±)-17, characterized by the 7-azabicylo[2.2.1]hept-2-ene ring, were prepared taking advantage of Pd-catalyzed cross-coupling reactions. The compounds were assayed for binding affinity at neuronal α4β2 and α7 nicotinic acetylcholine receptor subtypes.
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Authors
Clelia Dallanoce, Carlo Matera, Luca Pucci, Cecilia Gotti, Francesco Clementi, Marco De Amici, Carlo De Micheli,