| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595172 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A series of novel 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives were synthesized and characterized by IR, 1H NMR, HRMS spectroscopy and X-ray analysis. An apoptosis inducer for H322 lung cancer cell was discovered. Hoechst 33258 staining assay showed that the inhibition against H322 cell growth might be attributed to apoptosis.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cells](/preview/png/10595172.png "First Page Preview: Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cells")
Authors
Hong-Shui Lv, Xiang-Qian Kong, Qian-Qian Ming, Xing Jin, Jun-Ying Miao, Bao-Xiang Zhao,