Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595180 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
C-di-GMP has emerged as an important bacterial signaling molecule that is involved in biofilm formation. Small molecules that can form biologically inactive complexes with c-di-GMP have the potential to be used as anti-biofilm agents. Herein, we report that water-soluble diamidinium/iminium aromatics (such as berenil), which are traditionally considered as minor groove binders of nucleic acids, are capable of aggregating c-di-GMP into G-quadruplexes via Ï-stacking interactions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ilana Kelsey, Shizuka Nakayama, Herman O. Sintim,