| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595205 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of novel naphthalimide derivatives modified with various hydroxyl-alkylamines at 4-position have been synthesized. Their DNA binding properties were investigated by UV-Vis, fluoescence, and circular dichroism (CD) spectroscopies and thermal denaturation. The results showed that compounds 3a-e as the DNA intercalator exhibited middle binding affinities with Ct-DNA. The anticancer activities of 3a-e were preliminarily evaluated, compounds 3c and 3e exhibited potent anticancer activities against Bel-7402 cell line with IC50 values of 5.57 and 9.17 μM, respectively. More interestingly, enhancement of the fluorescence emission was found in the complexes of 3a-e with Ct-DNA, especially for 3c. This would make these compounds as potential DNA staining agents.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kerang Wang, Yueqing Wang, Xinhao Yan, Hua Chen, Gang Ma, Pingzhu Zhang, Jinmei Li, Xiaoliu Li, Jinchao Zhang,