Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

The synthesis of potent and liver-selective SCD inhibitors containing a bispyrrolidine as the tether joining the key heterocyclic core and terminal aromatic ring is described. Structure-activity relationships and in vivo biological activity of this new series of liver-targeting SCD inhibitors are reported.