| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595230 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED50 of 5.5Â mg/kg in an animal model of anticonvulsant activity after oral dosage.
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Authors
David Orain, Silvio Ofner, Manuel Koller, David A. Carcache, Wolfgang Froestl, Hans Allgeier, Vittorio Rasetti, Joachim Nozulak, Henri Mattes, Nicolas Soldermann, Philipp Floersheim, Sandrine Desrayaud, Joerg Kallen, Kurt Lingenhoehl, Stephan Urwyler,