| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595231 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anna Maria Almerico, Marco Tutone, Annalisa Guarcello, Antonino Lauria,