| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595267 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
In a series of bradykinin B1 antagonists, we discovered that replacement of oxopiperazine acetamides with dehydro-oxopiperazine acetamides provided compounds with enhanced activity against the B1 receptor. The synthesis and SAR leading to potent analogs with reduced molecular weight will be discussed.
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Authors
Wenyuan Qian, Jian Jeffrey Chen, Jason Human, Toshihiro Aya, Jiawang Zhu, Kaustav Biswas, Tanya Peterkin, Randall W. Hungate, Leyla Arik, Eileen Johnson, Gondi Kumar, Smriti Joseph, Janan Jona, Hong-Xun Guo, Zufan Wu,