| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595296 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
A novel series of DFMP/DFMS/ISD containing triaryl-sulfonamide derivatives (5a-r) are reported as potent PTP1B inhibitors. Some of the test compounds exhibits good selectivity towards PTP1B over various PTPs, including TCPTP (in vitro) and the lead compound 5o shows excellent antidiabetic activity (in vivo).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dipam Patel, Mukul Jain, Shailesh R. Shah, Rajesh Bahekar, Pradip Jadav, Amit Joharapurkar, Nirav Dhanesha, Mubeen Shaikh, Kalapatapu V.V.M. Sairam, Prashant Kapadnis,