Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595302 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
In pursuing our research on some 2,4-diamino-benzopyranopyrimidines and 2-amino-5,6-dihydrobenzo[h]quinazolines, previously reported as antiplatelet and analgesic/anti-inflammatory agents respectively, we designed and synthesized a new series of 5,6-dihydrobenzo[h]quinazoline 2,4-diamino substituted. The insertion of amino substituents at positions 2 and 4 of the benzoquinazoline scaffold resulted in compounds endowed with a potent ASA-like antiplatelet activity, combined with an anti-inflammatory activity comparable, in some cases, to that of indomethacin, used as a reference drug.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chiara Brullo, Massimo Rocca, Paola Fossa, Elena Cichero, Elisabetta Barocelli, Vigilio Ballabeni, Lisa Flammini, Carmine Giorgio, Francesca Saccani, Giuseppe Domenichini, Olga Bruno,