| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595308 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Novel macrocyclic Hsp90 inhibitors were identified through structure-based drug design. Among them, CH5164840 showed high binding affinity for Hsp90, potent anti-proliferative activity, high oral bioavailability in mice and potent antitumor efficacy in a human cancer xenograft model.
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Authors
Atsushi Suda, Hiroshi Koyano, Tadakatsu Hayase, Kihito Hada, Ken-ichi Kawasaki, Susumu Komiyama, Kiyoshi Hasegawa, Takaaki A. Fukami, Shigeo Sato, Takaaki Miura, Naomi Ono, Toshikazu Yamazaki, Ryoichi Saitoh, Nobuo Shimma, Yasuhiko Shiratori,