Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595320 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.
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Authors
Charlotte A.L. Lane, Duncan Hay, Charles E. Mowbray, Michael Paradowski, Matthew D. Selby, Nigel A. Swain, David H. Williams,