| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595340 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
High throughput screening of our chemical library for CRTH2 antagonists provided a lead compound 1a. Initial optimization of the lead led to the discovery of a novel, potent and orally bioavailable CRTH2 antagonist 17.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shinji Ito, Tadashi Terasaka, Tatsuya Zenkoh, Hiroshi Matsuda, Hisashi Hayashida, Hiroshi Nagata, Yoshimasa Imamura, Miki Kobayashi, Makoto Takeuchi, Mitsuaki Ohta,