Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595347 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A2α (cPLA2α). Signaling mediated by this class of bioactive lipids, which are collectively referred to as eicosanoids, has numerous effects in physiological and pathological processes. Herein, we report the development of a ligand-based pharmacophore model and pharmacophore-based virtual screening of the National Cancer Institute (NCI) database, leading to the identification of 4-(hexadecyloxy)-3-(2-(hydroxyimino)-3-oxobutanamido)benzoic acid (NSC 119957) as cPLA2α inhibitor in cell-free and cell-based in vitro assays.
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Authors
Stefan M. Noha, Bianca Jazzar, Susanne Kuehnl, Judith M. Rollinger, Hermann Stuppner, Anja M. Schaible, Oliver Werz, Gerhard Wolber, Daniela Schuster,