Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595387 | Bioorganic & Medicinal Chemistry Letters | 2013 | 24 Pages |
Abstract
In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, four series of novel cholesterol-based hydrazone derivatives were synthesized, and their insecticidal activity was tested against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1Â mg/mL. All the derivatives showed the better insecticidal activity than their precursor cholesterol. Quantitative structure-activity relationship (QSAR) model demonstrated that six descriptors such as RDF085v, Mor06u, Mor11u, Dv, HATS0v and H-046, are likely to influence the insecticidal activity of these compounds. Among them, two important ones are the Mor06u and RDF085v.
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Authors
Chun Yang, Yonghua Shao, Xiaoyan Zhi, Qu Huan, Xiang Yu, Xiaojun Yao, Hui Xu,