| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595416 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50 μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40-80 μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor.
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Authors
Deborah M. Ramsey, Md. Amirul Islam, Lynne Turnbull, Rohan A. Davis, Cynthia B. Whitchurch, Shelli R. McAlpine,