Article ID Journal Published Year Pages File Type
10595420 Bioorganic & Medicinal Chemistry Letters 2013 5 Pages PDF
Abstract
(−)-Codeine 1 was converted into previously unknown 7β-methyl-7,8-dihydrocodeine/morphine derivatives such as 13 via classical diaxial opening of α-epoxide 3. Several analogs exhibited dual μ/δ-agonist activity.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening
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