| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595438 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The synthesis and SAR profile of N-alkyl and heterocycle substituted 1,3-benzothiazin-4-one (BTZ) derivatives are described. The most potent compound 8o exhibits a MIC of 0.0001 μM against Mycobacterium tuberculosis H37Rv, 20-fold more potent than BTZ043 racemate.
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Authors
Chao Gao, Ting-Hong Ye, Ning-Yu Wang, Xiu-Xiu Zeng, Li-Dan Zhang, Ying Xiong, Xin-Yu You, Yong Xia, Ying Xu, Cui-Ting Peng, Wei-Qiong Zuo, Yuquan Wei, Luo-Ting Yu,