| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595466 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The optimization and truncation of our lead peptide-derived ligand TY005 possessing eight amino-acid residues was performed. Among the synthesized derivatives, NP30 (Tyr1-DAla2-Gly3-Phe4-Gly5-Trp6-O-[3â²,5â²-Bzl(CF3)2]) showed balanced and potent opioid agonist as well as substance P antagonist activities in isolated tissue-based assays, together with significant antinociceptive and antiallodynic activities in vivo.
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Authors
Padma Nair, Takashi Yamamoto, Tally M. Largent-Milnes, Scott Cowell, Vinod Kulkarni, Sharif Moye, Edita Navratilova, Peg Davis, Shou-Wu Ma, Todd W. Vanderah, Josephine Lai, Frank Porreca, Victor J. Hruby,