| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595477 | Bioorganic & Medicinal Chemistry Letters | 2013 | 6 Pages |
Abstract
Imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead were generated by whole cell screening of a focused library against Mycobacterium tuberculosis. Herein, we describe the synthesis and structure activity relationship evaluation of this class of inhibitors and the optimization of physicochemical properties. These are selective inhibitors of Mycobacterium tuberculosis with no activity on either gram positive or gram negative pathogens.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series](/preview/png/10595477.png "First Page Preview: Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series")
Authors
Sreekanth Ramachandran, Manoranjan Panda, Kakoli Mukherjee, Nilanjana Roy Choudhury, Subramanyam J. Tantry, Chaitanya Kumar Kedari, Vasanthi Ramachandran, Sreevalli Sharma, V.K. Ramya, Supreeth Guptha, Vasan K. Sambandamurthy,