Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595478 | Bioorganic & Medicinal Chemistry Letters | 2013 | 18 Pages |
Abstract
Three-component coupling of aldehyde, 2-hydroxy-1,4-naphthoquinone and 3-amino-1,2,4-triazole has been achieved using a catalytic amount of sulfamic acid under solvent free conditions to produce a novel series of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-dione derivatives in good yields and with high regioselectivity. These compounds are found to exhibit potent antitumoral properties.
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Authors
Liqiang wu, Chong Zhang, Weilin Li,