Article ID Journal Published Year Pages File Type
10595505 Bioorganic & Medicinal Chemistry Letters 2013 8 Pages PDF
Abstract
Phosphatidylinositol-3-kinase α (PI3Kα) is a therapeutic target of high interest in anticancer drug research. On the basis of a binding model rationalizing the high selectivity and potency of a particular series of 2-aminothiazole compounds in inhibiting PI3Kα, a medicinal chemistry program has led to the discovery of the clinical candidate NVP-BYL719.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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