Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595506 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The lipophilic amino acid, (S)-2-aminoundecanoic acid, was synthesized and incorporated at a number of specific positions within the peptide sequence of anoplin. These lipophilic anoplin analogs showed to be more active against Escherichia coli and Staphylococcus aureus compared to native anoplin, while the EC50-value of hemolysis was at least one order of magnitude lower than the MIC values. This was in sharp contrast to the N-acylated anoplin derivative, where a gain in activity also led to a complete loss of selectivity. Thus, the incorporation of a lipophilic amino acid residue into anoplin enhanced the antimicrobial activity, while selectivity towards microbial membranes was retained.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jack C. Slootweg, Timo B. van Schaik, H. (Linda) C. Quarles van Ufford, Eefjan Breukink, Rob M.J. Liskamp, Dirk T.S. Rijkers,