| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595517 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A series of dichloroplatinum(II) complexes of podophyllotoxin (PPT) were prepared, and their cytotoxicity against sensitive (A-549, HeLa, HCT-8, Hep-G2, K562) and resistant (ADM/K562) cell lines were evaluated. Complex cis-[4α-O-(2â³,3â³-diaminopropanoyl)-podophyllotoxin] dichloride platinum(II) (12) displayed most potent cytotoxicity with IC50 value in the range 0.071-2.98 μM. Complex 12 induces cell cycle arrest in the G2/M phase, and inhibits the formation of microtubules in HeLa cells. Furthermore, this complex exhibits potent DNA cleavage capabilities.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xuan Liu, Lin-Lin Zhang, Xiao-Hui Xu, Lin Hui, Jin-Bang Zhang, Shi-Wu Chen,