Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595518 | Bioorganic & Medicinal Chemistry Letters | 2013 | 11 Pages |
Abstract
Analogues of pyrrolo-[1,2,5]benzothiadiazepine were prepared and evaluated against Schistosoma japonica. The biological data revealed that most benzothiazepine derivatives show anti-schistosomal activity to some extent, while α-chloronation of the title compound and another bioisosteric derivative pyrrolo-[1,2,5]benzodiazepine displayed the most distinct worm killing activity. This study proved that benzodiazepine may serve as a novel structural skeleton for the development of anti-schistosomal agents.
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Authors
Jinglei Chen, Weizhen Sun, Jingjing Yang, Huan Sun, Zhixia Wang, Lanlan Dong, Chunhua Qiao, Chao-ming Xia,