| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595553 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Modulation of γ-secretase activity is a promising therapeutic strategy for the treatment of Alzheimer's disease. Herein we report on the synthesis of carprofen- and tocopherol-derived small-molecule modulators carrying terpene moieties as lipophilic membrane anchors. Additionally, these modulators are equipped with an acidic moiety, which contributes to the desired modulatory effect on the γ-secretase with decreased formation of Aβ42 and increased Aβ38 production.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eva Christine Naumann, Stefan Göring, Isabella Ogorek, Sascha Weggen, Boris Schmidt,