Article ID Journal Published Year Pages File Type
10595572 Bioorganic & Medicinal Chemistry Letters 2013 4 Pages PDF
Abstract
In this study, we synthesized the BF-3 binding small molecules, a series of pyridazinone-based compounds, as a novel class of non-LBP antiandrogens for treating prostate cancer by inhibiting androgen receptor. The new class compound was discovered to inhibitor the viability of AR-dependent human prostate LNCap cells and AR activity combining with the computational method. It showed a good physicochemical and PK property.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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