Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595572 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
In this study, we synthesized the BF-3 binding small molecules, a series of pyridazinone-based compounds, as a novel class of non-LBP antiandrogens for treating prostate cancer by inhibiting androgen receptor. The new class compound was discovered to inhibitor the viability of AR-dependent human prostate LNCap cells and AR activity combining with the computational method. It showed a good physicochemical and PK property.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Byung Jun Ryu, Nakjeong Kim, Jun Tae Kim, Tae-Sung Koo, Sung-Eun Yoo, Seo Hee Jeong, Seong Hwan Kim, Nam Sook Kang,