| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595604 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
A series of pyrazolopyrimidine mTOR inhibitors which contain basic amines or polar substituents attached to the 6-arylureidophenyl moiety demonstrate enhanced cellular potency and significantly improved stability towards human microsomes.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David J. Richard, Jeroen C. Verheijen, Kevin Curran, Joshua Kaplan, Lourdes Toral-Barza, Irwin Hollander, Judy Lucas, Ker Yu, Arie Zask,