| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595607 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
Bicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These analogues induce concentration-dependent degradation of Hsp90-dependent client proteins with the six-membered bicyclic analogues manifesting increased activity versus the five-membered counterparts.
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Authors
Vinod D. Jadhav, Adam S. Duerfeldt, Brian S.J. Blagg,