| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595661 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The structural modification of a series of [3.3.1] bicyclic sulfonamide based γ-secretase inhibitors is described. Appropriate substitution on the bicyclic scaffold provides a significant increase in the metabolic stability of the compounds resulting in an improved in vivo metabolic profile.
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Authors
Simeon Bowers, Gary D. Probst, Anh P. Truong, Roy K. Hom, Andrei W. Konradi, Hing L. Sham, Albert W. Garofalo, Karina Wong, Erich Goldbach, Kevin P. Quinn, John-Michael Sauer, William Wallace, Lan Nguyen, Susanna S. Hemphill, Michael P. Bova,