| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595681 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The synthesis and activity data of N-substituted carbazole- and O-substituted fenofibrate-derived γ-secretase modulators are presented. Out of 19 screened compounds, seven exhibited promising activity against Aβ42 secretion at a low micromolar level. We suggest that the γ-secretase modulators interact with lys624 at the membrane interface and that the lipophilic substituent anchors the compound in the membrane.
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Authors
Stefanie Baumann, Nicole Höttecke, Robert Schubenel, Karlheinz Baumann, Boris Schmidt,