Article ID Journal Published Year Pages File Type
10595699 Bioorganic & Medicinal Chemistry Letters 2011 4 Pages PDF
Abstract
CysQ is a 3′-phosphoadenosine-5′-phosphatase that dephosphorylates intermediates from the sulfate assimilation pathway of Mycobacterium tuberculosis (Mtb). Here, we demonstrate that cysQ disruption attenuates Mtb growth in vitro and decreases the biosynthesis of sulfated glycolipids but not major thiols, suggesting that the encoded enzyme specifically regulates mycobacterial sulfation.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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