| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595750 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach.
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Authors
Wenjun Wang, Lei Li, Chen Jin, Yujie Niu, Sen Li, Ji Ma, Linfeng Li, Yu Liu, Li Cai, Wei Zhao, Peng George Wang,