Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595760 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
The design and synthesis of an agarose resin functionalized with a Gram-negative quorum sensing (QS) signaling molecule analogue is described. The modified resin was utilized in affinity pull-down assays to successfully isolate QscR, a LuxR-type QS receptor from Pseudomonas aeruginosa. This resin may facilitate the identification of novel QS signal receptors using affinity chromatography techniques.
Related Topics
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Authors
Thanit Praneenararat, Teresa M.J. Beary, Anthony S. Breitbach, Helen E. Blackwell,