| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595779 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We have developed the first highly selective fluorescence probe for alkaline phosphatase (ALP), TG-mPhos. This probe shows selectivity for ALP over protein tyrosine phosphatase and protein serine/threonine phosphatase. Our previously developed TG-Phos, which has a phenolic phosphate linkage in place of the alcoholic phosphate linkage of TG-mPhos, lacks this selectivity. TG-mPhos should enable precise fluorescence imaging of ALP activity in biological applications.
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Authors
Mitsuyasu Kawaguchi, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tetsuo Nagano,