| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595785 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Autotaxin (ATX), an extracellular lysophospholipase D, is a target for anticancer therapeutics We describe the synthesis of a set of α-substituted phosphonate analogs of the poorly bioavailable S32826, and we show the effects of shortening the chain and adding α-halo or α-hydroxy substituents on ATX inhibition. An optimal compound was identified for examination of biological effects of ATX inhibition.
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Authors
Guowei Jiang, Damian Madan, Glenn D. Prestwich,