| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595796 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
The histone acetyltransferase R1109 is required for pathogenesis in several clinically important fungal species. Via a high throughput chemical screen of >300,000 compounds, we discovered a chemical inhibitor of R1109 that does not inhibit other acetyltransferase enzymes such as the yeast Gcn5 or human p300 enzymes.
Keywords
H3K56Ac-CoACOAPMSFDTNBHRPTBSN-ethylmaleimideIPTGPBSHTS5,5′-dithiobis-(2-nitrobenzoic acid)BSADMSOHPLC/MSphenylmethanesulfonylfluoridebovine serum albuminenzyme-linked immunosorbant assayacetyl-coenzyme Aisopropyl β-D-1-thiogalactopyranosideTris-buffered salineELISADimethyl sulfoxideSaccharomyces cerevisiaeHigh throughput screenPhosphate-buffered salineNEMHistone acetyltransferaseHorseradish peroxidaseCandida albicansHATcoenzyme A
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jessica Lopes da Rosa, Vineeta Bajaj, James Spoonamore, Paul D. Kaufman,