Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10595798 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Chemistry has been developed to access both imidazo[1,2-a]pyrazines and imidazo[1,2-c]pyrimidines. Small structural modifications in both series led to a switch of potency between two kinases involved in mediating cell cycle checkpoint control, CHK1 and MK2.
Related Topics
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Authors
Zhaoyang Meng, Jeffrey P. Ciavarri, Andrew McRiner, Yinyan Zhao, Lianyun Zhao, Panduranga Adulla Reddy, Xingmin Zhang, Thierry O. Fischmann, Charles Whitehurst, M. Arshad Siddiqui,