| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10595799 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The highly selective Ï1 receptor antagonist S1RA is endowed with a surprisingly high affinity for its target protein given a missing fundamental hydrophobic pharmacophoric requirement. Here we show that, with respect to other potent Ï1 ligands, S1RA is able to compensate this loss by fulfilling all other pharmacophoric requirements and by gaining in solvation energy
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Erik Laurini, Valentina Da Col, Bernhard Wünsch, Sabrina Pricl,